Drug Combination Details

General Information of the Combination (ID: C05210)
Name Metformin + Pioglitazone + Exenatide
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Name Metformin   NP Info     Drug Info 
Structure
Name    Drug Info 
Structure
Disease
Type 2 diabetes mellitus [ICD-11: 5A11]
Phase 2 [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    Experimental
                    Result(s)		 Metformin/pioglitazone/exenatide in patients with newly diagnosed T2DM is more effective and results in fewer hypoglycaemic events than sequential add-on therapy with metformin, sulfonylurea and then basal insulin.
References
Reference 1 ClinicalTrials.gov (NCT01396564) Pioglitazone and Metformin in Diabetic Children.
Reference 2 Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add-on therapy in subjects with new-onset diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes (EDICT): a randomized trial. Diabetes Obes Metab. 2015 Mar;17(3):268-75.
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