Drug Combination Details
| General Information of the Combination (ID: C05496) | |||||
|---|---|---|---|---|---|
| Name | Alpha linolenic acid NP Info | + | Riluzole Drug Info | ||
| Structure |
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+ |
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| Disease |
Stroke
[ICD-11: 8B20]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | KCNK2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | KCNK4 | Molecule Info | |||
| In-vivo Model | Focal ischemia was induced in adult male C57/Bl6 mice by occlusion of the left middle cerebral artery (MCA) using an intraluminal filament technique. | |||||
| Experimental
Result(s) |
Alpha-linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Alpha-linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia. Neuroscience. 2006;137(1):241-51. | |||
