Drug Combination Details
| General Information of the Combination (ID: C05942) | |||||
|---|---|---|---|---|---|
| Name | Resveratrol NP Info | + | Mitomycin C Drug Info | ||
| Structure |
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| Disease |
Colorectal cancer
[ICD-11: 2B91]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CCNB1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCNB2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
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| In-vitro Model | Cell lines established from resected colorectal tumor specimens | Colorectal cancer | Homo sapiens | |||
| Experimental
Result(s) |
Resveratrol enhances mitomycin C-mediated suppression of human colorectal cancer cell proliferation by up-regulation of p21WAF1/CIP1. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Resveratrol enhances mitomycin C-mediated suppression of human colorectal cancer cell proliferation by up-regulation of p21WAF1/CIP1. Anticancer Res. 2014 Oct;34(10):5439-46. | |||
