Drug Combination Details
| General Information of the Combination (ID: C06415) | |||||
|---|---|---|---|---|---|
| Name | Acteoside NP Info | + | Temozolomide Drug Info | ||
| Structure |
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| Disease |
Brain cancer
[ICD-11: 2A00]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Reversing Drug Resistance by This Combination | ||||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CD107a | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | JNK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | p38 beta | Molecule Info |
Pathway MAP
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| In-vitro Model | C6 | CVCL_0194 | Rat malignant glioma | Rattus norvegicus | ||
| Experimental
Result(s) |
Acteoside has beneficial effects on TMZ based glioblastoma therapy. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic anticancer effect of acteoside and temozolomide-based glioblastoma chemotherapy. Int J Mol Med. 2019 Mar;43(3):1478-1486. | |||
