Drug Combination Details
| General Information of the Combination (ID: C06615) | |||||
|---|---|---|---|---|---|
| Name | Capsaicin NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
|
|
| Down-regulation | Expression | ATG3 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | BECN1 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Phosphorylation | S6K1 | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | QBC939 | CVCL_6942 | Cholangiocarcinoma | Homo sapiens | ||
| SK-ChA-1 | CVCL_6952 | Cholangiocarcinoma | Homo sapiens | |||
| Mz-ChA-1 | CVCL_6932 | Gallbladder carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Capsaicin enhances 5FU sensitivity of cholangiocarcinoma through the inhibition of 5FU-induced autophagy by activating the PI3K/AKT/mTOR pathway. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Capsaicin Enhances the Drug Sensitivity of Cholangiocarcinoma through the Inhibition of Chemotherapeutic-Induced Autophagy. PLoS One. 2015 May 1;10(5):e0121538. | |||
