Drug Combination Details

General Information of the Combination (ID: C06962)
Name Echinocandin   NP Info  + Amphotericin B   Drug Info 
Structure +
Disease
Candidosis [ICD-11: 1F23]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vivo Model C57BL/6N female mice, immunosuppressed with cyclophosphamide, were challenged intravenously via the tail vein with 1.0 * 107 C. glabrata.
                    Experimental
                    Result(s)		 The combination of liposomal amphotericin B with an echinocandin markedly improved the therapeutic outcome in murine C. glabrata systemic infection.
References
Reference 1 Treatment of Candida glabrata infection in immunosuppressed mice by using a combination of liposomal amphotericin B with caspofungin or micafungin. Antimicrob Agents Chemother. 2005 Dec;49(12):4895-902.
 Download Picture         KEGG Link