Natural Product (NP) Details
| General Information of the NP (ID: NP2151) | |||||
|---|---|---|---|---|---|
| Name |
Echinocandin
|
||||
| Species Origin | Glarea lozoyensis ... | Click to Show/Hide | |||
| Glarea lozoyensis | |||||
| Disease | Candidosis [ICD-11: 1F23] | Investigative | [1] | ||
| TTD Drug ID | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Amphotericin B | Fungal infection | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
|||||
| In-vivo Model | C57BL/6N female mice, immunosuppressed with cyclophosphamide, were challenged intravenously via the tail vein with 1.0 * 107 C. glabrata. | |||||
| Experimental
Result(s) |
The combination of liposomal amphotericin B with an echinocandin markedly improved the therapeutic outcome in murine C. glabrata systemic infection. | |||||
