Drug Combination Details
| General Information of the Combination (ID: C07748) | |||||
|---|---|---|---|---|---|
| Name | Resveratrol NP Info | + | Flutamide Drug Info | ||
| Structure |
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+ |
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| Disease |
Prostate cancer
[ICD-11: 2C82]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | AR | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | LNCaP | CVCL_0395 | Prostate carcinoma | Homo sapiens | ||
| PC-3 | CVCL_0035 | Prostate carcinoma | Homo sapiens | |||
| DU145 | CVCL_0105 | Prostate carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
The combination of resveratrol with flutamide had a synergistic effect on down-regulation of androgen receptor (AR). | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination of resveratrol and antiandrogen flutamide has synergistic effect on androgen receptor inhibition in prostate cancer cells. Anticancer Res. 2011 Oct;31(10):3323-30. | |||
