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Drug Combination Details

General Information of the Combination (ID: C07781)
Name Paclitaxel   NP Info  + Gemcitabine   Drug Info 
Structure +
Disease
Pancreatic cancer [ICD-11: 2C10]
Phase 4 [1]
Breast cancer [ICD-11: 2C60]
Investigative [2]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vivo Model Clinical trial review
                    Experimental
                    Result(s)
The combination was very well tolerated and was not associated with any adverse impact in quality of life compared with paclitaxel alone.
References
Reference 1 ClinicalTrials.gov (NCT02812992) Geriatric Assessment Directed Trial to Evaluate Gemcitabine +/- Nab-paclitaxel in Elderly Pancreatic Cancer Patients (GrantPax).
Reference 2 Gemcitabine plus paclitaxel in breast cancer. Semin Oncol. 2005 Aug;32(4 Suppl 6):S14-21.
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Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China