Drug Combination Details
| General Information of the Combination (ID: C08951) | |||||
|---|---|---|---|---|---|
| Name | Saponin NP Info | + | Synthetic lipid A Drug Info | ||
| Structure |
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| Disease |
West nile virus infection
[ICD-11: 1D46]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Induction | A diverse antibody response | ||||
| In-vivo Model | For murine challenge studies, 6 to 8-week-old female C57Bl/6 mice were challenged with 105 plaque forming units (PFU) of WNV via intraperitoneal injection of virus in 0.25 mL total volume. | |||||
| Experimental
Result(s) |
A combination of TLR-4 agonist and saponin adjuvants increases antibody diversity and protective efficacy of a recombinant West Nile Virus antigen. | |||||
