Drug Details
| General Information of the Drug (ID: DR6255) | ||||
|---|---|---|---|---|
| Name |
Synthetic lipid A
|
|||
| Disease | Vaccination [ICD-11: N.A.] | Investigative | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Saponin | Panax ginseng | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
|||||
| Biological
Regulation |
Induction | A diverse antibody response | ||||
| In-vivo Model | For murine challenge studies, 6 to 8-week-old female C57Bl/6 mice were challenged with 105 plaque forming units (PFU) of WNV via intraperitoneal injection of virus in 0.25 mL total volume. | |||||
| Experimental
Result(s) |
A combination of TLR-4 agonist and saponin adjuvants increases antibody diversity and protective efficacy of a recombinant West Nile Virus antigen. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Thymidylate synthase (TYMS) | Molecule Info | [3] | |
