Drug Combination Details
| General Information of the Combination (ID: C09339) | |||||
|---|---|---|---|---|---|
| Name | Ceramide NP Info | + | Docetaxel Drug Info | ||
| Structure |
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| Disease |
Melanoma
[ICD-11: 2C30]
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Investigative | [1] | ||
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Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Induction | Apoptosis | ||||
| Induction | Cell cycle arrest in S and G2/M phase | |||||
| In-vitro Model | B16 | CVCL_F936 | Mouse melanoma | Mus musculus | ||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| In-vivo Model | B16 tumor-bearing mice. Kunming mice (18-22 g) was inoculated with B16 melanoma cells (3 * 105) by subcutaneously injection at the right axillary space. | |||||
| Experimental
Result(s) |
Ceramide could enhance the antitumor activity of Docetaxel in a synergistic manner, which suggest promising application prospects of Ceramide + Docetaxel combination treatment. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic enhancement of cancer therapy using a combination of ceramide and docetaxel. Int J Mol Sci. 2014 Mar 10;15(3):4201-20. | |||
