Natural Product (NP) Details
| General Information of the NP (ID: NP6170) | |||||
|---|---|---|---|---|---|
| Name |
Ceramide
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| Species Origin | Ananas comosus ... | Click to Show/Hide | |||
| Ananas comosus | |||||
| Disease | Breast cancer [ICD-11: 2C60] | Phase 2 | [1] | ||
| Herb ID | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| N, N-dimethyl-D-erythro-sphingosine | Colon cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Increase | Mitochondrial membrane potential loss | ||||
| In-vitro Model | LL/2 (LLC1) | CVCL_4358 | Malignant tumors | Mus musculus | ||
| Experimental
Result(s) |
The radiosensitizing activity of ceramide/DMS on LLC cells most likely reflects the dominance of pro-apoptotic signals related to the mitochondria-dependent pathway. | |||||
| Docetaxel | Solid tumour/cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Biological
Regulation |
Induction | Apoptosis | ||||
| Induction | Cell cycle arrest in S and G2/M phase | |||||
| In-vitro Model | B16 | CVCL_F936 | Mouse melanoma | Mus musculus | ||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| In-vivo Model | B16 tumor-bearing mice. Kunming mice (18-22 g) was inoculated with B16 melanoma cells (3 * 105) by subcutaneously injection at the right axillary space. | |||||
| Experimental
Result(s) |
Ceramide could enhance the antitumor activity of Docetaxel in a synergistic manner, which suggest promising application prospects of Ceramide + Docetaxel combination treatment. | |||||
