Drug Combination Details
| General Information of the Combination (ID: C09745) | |||||
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| Name | Cinchonine | + | Hydrocinchonine + Quinidine | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Cinchonine NP Info | Drug Info | |||
| Structure |
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| Name | Drug Info | ||||
| Structure |
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| Disease |
Uterine Sarcoma
[ICD-11: 2B5F]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Reversing Drug Resistance by This Combination | ||||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | ABCB1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | MES-SA | CVCL_1404 | Uterine corpus sarcoma | Homo sapiens | ||
| MES-SA/Dx5 | CVCL_2598 | Uterine corpus sarcoma | Homo sapiens | |||
| Experimental
Result(s) |
Hydrocinchonine exerted MDR reversal activity and synergistic apoptotic effect with TAX in MES-SA/DX5 cells almost comparable with quinidine and cinchonine as a potent MDR-reversal and combined therapy agent with TAX. | |||||
