Drug Combination Details
| General Information of the Combination (ID: C11135) | |||||
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| Name | Atractylodes macrocephala + Panax ginseng total saponins | + | 5-fluorouracil | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Atractylodes macrocephala NP Info | Drug Info | |||
| Structure |
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| Name | Panax ginseng total saponins NP Info | ||||
| Structure |
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| Disease |
Diarrhea
[ICD-11: ME05]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | The mice were administered with AMO, PGS and AP respectively for 11 days, and intraperitoneally injected with 5-FU for 6 days since the 3rd day of the experiment. | |||||
| Experimental
Result(s) |
Combination of AMO and PGS, not AMO or PGS alone, significantly ameliorated diarrhea, inhibited intestinal pathology, and modulated gut microbial structure in 5-FU induced mice. | |||||
