Drug Combination Details
| General Information of the Combination (ID: C11162) | |||||
|---|---|---|---|---|---|
| Name | Noscapine NP Info | + | Radiation Drug Info | ||
| Structure |
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| Disease |
Brain cancer
[ICD-11: 2A00]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Up-regulation | Apoptosis | ||||
| In-vitro Model | T98G | CVCL_0556 | Glioblastoma | Homo sapiens | ||
| GL261 | CVCL_Y003 | Mouse glioblastoma | Mus musculus | |||
| Murine endothelial cell line 2H11 | Healthy | Rattus norvegicus | ||||
| In-vivo Model | For a xenograft model, 2.0 * 106 GL261 cells were injected subcutaneously in the hind limof mice. | |||||
| Experimental
Result(s) |
Antiangiogenic effects of noscapine enhance radioresponse for GL261 tumors. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Antiangiogenic effects of noscapine enhance radioresponse for GL261 tumors. Int J Radiat Oncol Biol Phys. 2008 Aug 1;71(5):1477-84. | |||
