| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
| α. Enhancing Drug Efficacy by This Combination |
| Achieving Therapeutic Synergy |
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| Experiment 1 Reporting the Effect of This Combination |
[1] |
| In-vitro Model |
HL-60 |
CVCL_0002
|
Adult acute myeloid leukemia |
Homo sapiens |
| U-937 |
CVCL_0007
|
Adult acute monocytic leukemia |
Homo sapiens |
| K-562 |
CVCL_0004
|
Chronic myelogenous leukemia |
Homo sapiens |
| OCI-AML-3 |
CVCL_1844
|
Adult acute myeloid leukemia |
Homo sapiens |
Experimental
Result(s) |
Combination of Azacitidine and curcumin showed a synergy in all leukemic lines and in most leukemic samples, with a decrease in proliferation and an increase in apoptosis compared to the activity of each drug separately. Azacitidine plus curcumin showed low cytotoxicity in healthy samples. |
