Drug Combination Details

General Information of the Combination (ID: C12369)
Name Cucurbitacin E   NP Info  + Doxorubicin   Drug Info 
Structure +
Disease
Stomach cancer [ICD-11: 2B72]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model NCI-N87 CVCL_1603 Gastric tubular adenocarcinoma Homo sapiens
BGC-823 CVCL_3360 Gastric cancer Homo sapiens
SNU-16 CVCL_0076 Gastric adenocarcinoma Homo sapiens
SGC-7901 CVCL_0520 Human gastric cancer Homo sapiens
MGC-803 CVCL_5334 Gastric mucinous adenocarcinoma Homo sapiens
                    In-vivo Model Female BALB/c nude mice (4-5 weeks old) were subcutaneously injected with 1*107 NCI-N87 cells (suspended in 100 ul of PBS with 50% Matrigel) to establish tumors.
                    Experimental
                    Result(s)		 Cucurbitacin E inhibits cellular proliferation and enhances the chemo-response in gastric cancer by suppressing AKt activation.
References
Reference 1 Cucurbitacin E inhibits cellular proliferation and enhances the chemo-response in gastric cancer by suppressing AKt activation. J Cancer. 2019 Oct 6;10(23):5843-5851.
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