Drug Combination Details
| General Information of the Combination (ID: C14201) | |||||
|---|---|---|---|---|---|
| Name | Morphine NP Info | + | Methylphenidate Drug Info | ||
| Structure |
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+ |
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| Disease |
Pain
[ICD-11: MG30-MG3Z]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Increase | Antinociceptive effect | ||||
| In-vivo Model | Adult male Sprague-Dawley rats weighing 250-270 g were used in this study. | |||||
| Experimental
Result(s) |
A combination therapy using low-dose MPH and MOR may produce a MOR-sparing effect in chronic pain management. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Methylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain. Anesth Analg. 2020 Feb;130(2):518-524. | |||
