Drug Combination Details
| General Information of the Combination (ID: C14803) | |||||
|---|---|---|---|---|---|
| Name | Honokiol NP Info | + | Bleomycin Drug Info | ||
| Structure |
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| Disease |
Lung cancer
[ICD-11: 2C25]
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Investigative | [1] | ||
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Breast cancer
[ICD-11: 2C60]
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Investigative | [1] | |||
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Pancreatic cancer
[ICD-11: 2C10]
|
Investigative | [1] | |||
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Melanoma
[ICD-11: 2C30]
|
Investigative | [1] | |||
| Click to Show/Hide the Whole Disease Information of This Combination | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Activity | POLB | Molecule Info |
Pathway MAP
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| Down-regulation | Activity | POLL | Molecule Info |
Pathway MAP
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| In-vitro Model | A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | ||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| PANC-1 | CVCL_0480 | Pancreatic ductal adenocarcinoma | Homo sapiens | |||
| UACC-903 | CVCL_4052 | Cutaneous melanoma | Homo sapiens | |||
| Experimental
Result(s) |
Honokiol inhibits DNA polymerases Beta and Lambda and increases Bleomycin sensitivity of human cancer cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Honokiol Inhibits DNA Polymerases Beta and Lambda and Increases Bleomycin Sensitivity of Human Cancer Cells. Chem Res Toxicol. 2017 Feb 20;30(2):715-725. | |||
