Drug Combination Details
| General Information of the Combination (ID: C17335) | |||||
|---|---|---|---|---|---|
| Name | Glycine NP Info | + | Loxoprofen Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Nocturia
[ICD-11: MF55]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Female Sprague-Dawley rats, weighing 200-250 g (10-12-week-old), were used in this study. | |||||
| Experimental
Result(s) |
The combined administration of loxoprofen and glycine produced a synergistic inhibitory effect on the micturition reflex. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic effects of loxoprofen and glycine on the micturition reflex in conscious rats. Biomed Res. 2014;35(1):17-23. | |||
