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Natural Product (NP) Details

General Information of the NP (ID: NP4960)
Name
Glycine
Synonyms
glycine; 2-Aminoacetic acid; 56-40-6; aminoacetic acid; Glycocoll; Aminoethanoic acid; Glycolixir; Padil; Glycosthene; Aciport; Glicoamin; L-Glycine; H-Gly-OH; Hampshire glycine; Amitone; Leimzucker; Acetic acid, amino-; Aminoazijnzuur; Glycine, non-medical; Sucre de gelatine; Gyn-hydralin; GLY (IUPAC abbrev); polyglycine; Glycinum; Corilin; Glycinum [INN-Latin]; Glicina [INN-Spanish]; Glycine [INN]; glycyl radical; Glyzin; FEMA No. 3287; gly; Acide aminoacetique [INN-French]; Acido aminoacetico [INN-Spanish]; Acidum aminoaceticum [INN-Latin]; MFCD00008131; CCRIS 5915; HSDB 495; AI3-04085; amino-Acetic acid; UNII-TE7660XO1C; NSC 25936; [14C]glycine; CHEMBL773; Glycine iron sulphate (1:1); TE7660XO1C; 25718-94-9; CHEBI:15428; 2-aminoaceticacid; AZD-4282; NSC25936; Athenon; NSC-25936; NCGC00024503-01; Glicina; DSSTox_CID_667; Glycine, free base; Polyglycine II; Acido aminoacetico; Acide aminoacetique; DSSTox_RID_75720; DSSTox_GSID_20667; Acidum aminoaceticum; Glycine, 99%, ACS reagent; Glycine, 99+%, for analysis; Glykokoll; Aminoessigsaeure; Hgly; CAS-56-40-6; Glycine, labeled with carbon-14; Glycine [USP:INN]; GLYCINE 1.5% IN PLASTIC CONTAINER; EINECS 200-272-2; H2N-CH2-COOH; AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER; Glycine, homopolymer (VAN); Aminoethanoate; amino-Acetate; 2-aminoacetate; Glycine;; glycine USP; Glycine Technical; glycine-13c; [3H]glycine; Glycine, EP/USP; H-Gly; L-Gly; Gly-CO; Gly-OH; L-Glycine,(S); [14C]-glycine; Corilin (Salt/Mix); 112898-03-0; Glycine 1 M solution; PubChem18924; Tocris-0219; Glycine (H-Gly-OH); NH2CH2COOH; Glycine, >=99%; Glycine (JP17/USP); Glycine, 99%, FCC; Glycine-1,2-13C2; Biomol-NT_000195; bmse000089; bmse000977; WLN: Z1VQ; EC 200-272-2; H-[15N]Gly-OH; Gly-253; GTPL727; AB-131/40217813; Glycine [for Electrophoresis]; GLYCINE, [2-3H]; Glycine, Electrophoresis Grade; BPBio1_001222; GTPL4084; GTPL4635; N[C]C(O)=O; DTXSID9020667; BDBM18133; Buffer Concentrate, pH 11.01; AZD4282; Glycine, >=99.0% (NT); Glycine, 98.5-101.5%; Pharmakon1600-01300021; 2-Aminoacetic acid;Aminoacetic acid; BCP25965; CS-B1641; HY-Y0966; ZINC4658552; Glycine, ACS reagent, >=98.5%; Tox21_113575; 2-amino-1-$l^{1}-oxidanylethanone; ANW-32505; Glycine, 99%, natural, FCC, FG; NSC760120; s4821; STL194276; Glycine, purum, >=98.5% (NT); Glycine, tested according to Ph.Eur.; AKOS000119626; Glycine, for electrophoresis, >=99%; Tox21_113575_1; AM81781; CCG-266010; DB00145; MCULE-2415764032; NSC-760120; Glycine, BioUltra, >=99.0% (NT); Glycine, BioXtra, >=99% (titration); Glycine, SAJ special grade, >=99.0%; NCGC00024503-02; NCGC00024503-03; 18875-39-3; AK-77854; BP-31024; Glycine, Vetec(TM) reagent grade, 98%; Glycine, 0.2M buffer solution, pH 2.5; Glycine, 0.2M buffer solution, pH 3.0; Glycine, 0.2M buffer solution, pH 3.5; DB-029870; FT-0600491; FT-0669038; G0099; G0317; Glycine, ReagentPlus(R), >=99% (HPLC); A20662; C00037; D00011; M-6155; M03001; L001246; Q620730; SR-01000597729; Glycine, certified reference material, TraceCERT(R); Q-201300; SR-01000597729-1; Q27115084; B72BA06C-60E9-4A83-A24A-A2D7F465BB65; F2191-0197; Glycine, European Pharmacopoeia (EP) Reference Standard; Z955123660; Glycine, BioUltra, for molecular biology, >=99.0% (NT); UNII-0O72R8RF8A component DHMQDGOQFOQNFH-UHFFFAOYSA-N; Glycine, United States Pharmacopeia (USP) Reference Standard; Glycine, Pharmaceutical Secondary Standard; Certified Reference Material; Tris-tricine buffer; Tris-glycine buffer;Tris glycine buffer concentrate; Glycine, analytical standard, for nitrogen determination according to Kjeldahl method; 21931-03-3; Glycine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, >=98.5%; Glycine, meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance); Glycine, PharmaGrade, Ajinomoto, EP, JP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture; Glycine, puriss. p.a., Reag. Ph. Eur., buffer substance, 99.7-101% (calc. to the dried substance)
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Species Origin Musa x paradisiaca ...     Click to Show/Hide
Musa x paradisiaca
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Zingiberales
Family: Musaceae
Genus: Musa
Species: Musa x paradisiaca
Disease Nutritional deficiency [ICD-11: 5B55-5B71] Approved [1]
Structure
Click to Download Mol
2D MOL

3D MOL

    Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product
Formula
C2H5NO2
PubChem CID
750
Canonical SMILES
C(C(=O)O)N
InChI
1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKey
DHMQDGOQFOQNFH-UHFFFAOYSA-N
CAS Number
CAS 56-40-6
ChEBI ID
CHEBI:15428
Herb ID
HBIN028135
SymMap ID
SMIT15647
TTD Drug ID
D0M8AB
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Loxoprofen      Ankylosing spondylitis     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Female Sprague-Dawley rats, weighing 200-250 g (10-12-week-old), were used in this study.
                    Experimental
                    Result(s)
The combined administration of loxoprofen and glycine produced a synergistic inhibitory effect on the micturition reflex.
    β. A List of Drug(s) Whose Adverse Effect can be Decreased by This NP
          Folfox      Colorectal cancer     Click to Show/Hide the Molecular Data of This Drug
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation
Up-regulation Expression FABP3  Molecule Info 
Pathway MAP
                    In-vitro Model Human cardiac myocytes Healthy Homo sapiens
                    In-vivo Model For a xenograft model, CC531 cells were injected into the right liver lobe of seven-week-old male Wag/Rij rats.
                    Experimental
                    Result(s)
Dietary glycine protects the heart against FOLFOX-induced injury during treatment for CRLM.
Target and Pathway
Target(s) Glutamate receptor ionotropic NMDA 2A (NMDAR2A)  Molecule Info  [4]
KEGG Pathway Ras signaling pathway Click to Show/Hide
2 Rap1 signaling pathway
3 Calcium signaling pathway
4 cAMP signaling pathway
5 Neuroactive ligand-receptor interaction
6 Circadian entrainment
7 Long-term potentiation
8 Glutamatergic synapse
9 Dopaminergic synapse
10 Alzheimer's disease
11 Amyotrophic lateral sclerosis (ALS)
12 Cocaine addiction
13 Amphetamine addiction
14 Nicotine addiction
15 Alcoholism
16 Systemic lupus erythematosus
Panther Pathway Huntington disease Click to Show/Hide
2 Ionotropic glutamate receptor pathway
3 Metabotropic glutamate receptor group III pathway
4 Metabotropic glutamate receptor group I pathway
5 Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database Reelin signaling pathway Click to Show/Hide
Reactome Unblocking of NMDA receptor, glutamate binding and activation Click to Show/Hide
2 CREB phosphorylation through the activation of CaMKII
3 Ras activation uopn Ca2+ infux through NMDA receptor
4 RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction Click to Show/Hide
2 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
3 Alzheimers Disease
References
Reference 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 727).
Reference 2 Synergistic effects of loxoprofen and glycine on the micturition reflex in conscious rats. Biomed Res. 2014;35(1):17-23.
Reference 3 Dietary Glycine Prevents FOLFOX Chemotherapy-Induced Heart Injury: A Colorectal Cancer Liver Metastasis Treatment Model in Rats. Nutrients. 2020 Aug 28;12(9):2634.
Reference 4 Glycine transport inhibitors for the treatment of schizophrenia: Symptom and disease modification. Curr Opin Drug Discov Devel. 2009 Jul;12(4):468-78.
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Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China