Drug Combination Details
| General Information of the Combination (ID: C17530) | |||||
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| Name | Fluoroorotic acid | + | Uftoral + Oxaliplatin | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Fluoroorotic acid NP Info | Drug Info | |||
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| Disease |
Colon cancer
[ICD-11: 2B90]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | ||
| In-vivo Model | Human colorectal HT29 cell xenografts (1*106 cells) were transplanted s.c. into the hind limb of each animal (Female BALB/c nude mice (nu+/nu+) aged 6 weeks). | |||||
| Experimental
Result(s) |
Combined treatment (UFT/FA+oxaliplatin) reduced tumor weight by 39% compared to oxaliplatin alone (p<0.05) or UFT/FA (p<0.05). | |||||
