Drug Details
| General Information of the Drug (ID: DR2378) | ||||
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| Name |
Uftoral
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| Synonyms |
Tegafur-Uracil; Ufur; Uftoral; 74578-38-4; UFT; Youfuding; Uracil-Tegafur; orzel; Tegafur - uracil mixture; Tegafur / uracil; UFT(R) drug; FT mixt. with uracil (1:4); Uracil mixt. with FT (4:1); Tegafur Mixture With With Uracil; Tegafur mixt. with uracil (1:4); Uracil mixt. with tegafur (4:1); Tegafur/uracil; Tegafur and uracil; Uftoral (TN); 1-(2-Tetrahydrofuryl)-5-fluorouracil mixt. with uracil (1:4); Uracil mixt. with 1-(2-tetrahydrofuryl)-5-fluorouracil (4:1); SCHEMBL8228; DTXSID3023635; Uracil, 5-fluoro-1-(tetrahydro-2-furyl)- mixt. with uracil (1:4); DB09327; 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-, mixt. with 2,4(1H,3H)-pyrimidinedione; D02131; 117638-EP2270505A1; 117638-EP2295426A1; 117638-EP2295427A1; 117638-EP2298768A1; Q27098002; 5-fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione;1H-pyrimidine-2,4-dione; 5-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione - pyrimidine-2,4(1H,3H)-dione (1:1)
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| Molecular Type |
Small molecule
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| Disease | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | Approved | [1] | |
| Structure |
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| Formula |
C12H13FN4O5
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| PubChem CID | ||||
| Canonical SMILES |
C1CC(OC1)N2C=C(C(=O)NC2=O)F.C1=CNC(=O)NC1=O
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| InChI |
1S/C8H9FN2O3.C4H4N2O2/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12;7-3-1-2-5-4(8)6-3/h4,6H,1-3H2,(H,10,12,13);1-2H,(H2,5,6,7,8)
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| InChIKey |
DHMYGZIEILLVNR-UHFFFAOYSA-N
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| CAS Number |
CAS 74578-38-4
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| TTD Drug ID | ||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Fluoroorotic acid | Homo sapiens | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| In-vitro Model | HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | ||
| In-vivo Model | Human colorectal HT29 cell xenografts (1*106 cells) were transplanted s.c. into the hind limb of each animal (Female BALB/c nude mice (nu+/nu+) aged 6 weeks). | |||||
| Experimental
Result(s) |
Combined treatment (UFT/FA+oxaliplatin) reduced tumor weight by 39% compared to oxaliplatin alone (p<0.05) or UFT/FA (p<0.05). | |||||
