Drug Combination Details

General Information of the Combination (ID: C19645)
Name Curcumin   NP Info  + Sunitinib   Drug Info 
Structure +
Disease
Renal cell carcinoma [ICD-11: 2C90]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Decreasing Adverse Drug Reaction by This Combination
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Down-regulation Expression CDK1  Molecule Info 
Pathway MAP
Down-regulation Expression CDK4  Molecule Info 
Pathway MAP
Down-regulation Phosphorylation RB1  Molecule Info 
Pathway MAP
                    In-vitro Model 786-O CVCL_1051 Renal cell carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Curcumin potentiates the ability of sunitinib to eliminate the VHL-lacking renal cancer cells 786-O.
References
Reference 1 Curcumin potentiates the ability of sunitinib to eliminate the VHL-lacking renal cancer cells 786-O: rapid inhibition of Rb phosphorylation as a preamble to cyclin D1 inhibition. Anticancer Agents Med Chem. 2013 Dec;13(10):1508-13.
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