Drug Combination Details

General Information of the Combination (ID: C20591)
Name Methyl gallate   NP Info  + Marbofloxacin   Drug Info 
Structure +
Disease
Salmonella infection [ICD-11: 1A09]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vivo Model Salmonella Typhimurium in rats were used in this study.
                    Experimental
                    Result(s)		 MG has shown to increase the antimicrobial activity of MAR in vitro and ex vivo experiments without affecting the pharmacokinetics of MAR in rats.
References
Reference 1 Evaluation of the pharmacokinetic-pharmacodynamic integration of marbofloxacin in combination with methyl gallate against Salmonella Typhimurium in rats. PLoS One. 2020 Jun 4;15(6):e0234211.
Reference 2 Inhibition of Salmonella Typhimurium adhesion, invasion, and intracellular survival via treatment with methyl gallate alone and in combination with marbofloxacin. Vet Res. 2018 Oct 4;49(1):101.
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