Natural Product (NP) Details

General Information of the NP (ID: NP4688)
Name
Methyl gallate
Synonyms
METHYL GALLATE; Methyl 3,4,5-trihydroxybenzoate; 99-24-1; Gallic acid methyl ester; Methylgallate; Benzoic acid, 3,4,5-trihydroxy-, methyl ester; Gallic acid, methyl ester; methyl galloate; MFCD00002194; UNII-623D3XG80C; 3,4,5-Trihydroxybenzoic acid methyl ester; AI3-00861; 3,4,5-Trihydroxy-benzoic acid methyl ester; CHEMBL65675; 623D3XG80C; NSC363001; Methyl 3,4,5-trihydroxybenzoate, 99%; GALLINCIN; CCRIS 5567; EINECS 202-741-7; NSC 363001; BRN 2113180; Methyl gallate;; methyl-3,4,5-trihydroxybenzoate; Gallic acid methyl; ACMC-209sc1; cid_7428; SCHEMBL39513; 4-10-00-01998 (Beilstein Handbook Reference); MLS000574912; DTXSID3059189; ZINC21789; CHEBI:145828; HMS2210A23; HMS3346G16; ACT10740; HY-N2010; ANW-40991; BBL010505; BDBM50187133; CM0133; s3790; SBB064246; STL146151; methyl 3,4,5-tris(oxidanyl)benzoate; AKOS000277450; CCG-266463; EBD1614516; MCULE-4626719858; NSC-363001; Methyl 3,4,5-trihydroxybenzoate, 98%; NCGC00247606-01; AC-11364; AK-94175; AS-14808; M666; SMR000156263; SY011144; AB0007856; DB-057768; CS-0018330; FT-0626596; G0017; H6235; ST50825211; A845986; CS-008/03903045; W-100047; Q15425833
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Species Origin Givotia rottleriformis ...     Click to Show/Hide
Givotia rottleriformis
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Malpighiales
Family: Euphorbiaceae
Genus: Givotia
Species: Givotia rottleriformis
Disease Brain cancer [ICD-11: 2A00] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C8H8O5
PubChem CID
7428
Canonical SMILES
COC(=O)C1=CC(=C(C(=C1)O)O)O
InChI
1S/C8H8O5/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,9-11H,1H3
InChIKey
FBSFWRHWHYMIOG-UHFFFAOYSA-N
CAS Number
CAS 99-24-1
ChEBI ID
CHEBI:145828
Herb ID
HBIN035224
SymMap ID
SMIT04254
TCMSP ID
MOL001906
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Marbofloxacin      Chronic obstructive pulmonary disease     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Salmonella Typhimurium in rats were used in this study.
                    Experimental
                    Result(s)		 MG has shown to increase the antimicrobial activity of MAR in vitro and ex vivo experiments without affecting the pharmacokinetics of MAR in rats.
References
Reference 1 Antitumor activity of methyl gallate by inhibition of focal adhesion formation and Akt phosphorylation in glioma cells. Biochim Biophys Acta. 2013 Aug;1830(8):4017-29.
Reference 2 Evaluation of the pharmacokinetic-pharmacodynamic integration of marbofloxacin in combination with methyl gallate against Salmonella Typhimurium in rats. PLoS One. 2020 Jun 4;15(6):e0234211.
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