Drug Combination Details
| General Information of the Combination (ID: C20718) | |||||
|---|---|---|---|---|---|
| Name | Phenethyl isothiocyanate NP Info | + | Dibenzoylmethane Drug Info | ||
| Structure |
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+ |
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| Disease |
Prostate cancer
[ICD-11: 2C82]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
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| Down-regulation | Activity | p105 | Molecule Info |
Pathway MAP
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| In-vitro Model | DU145 | CVCL_0105 | Prostate carcinoma | Homo sapiens | ||
| PC-3 | CVCL_0035 | Prostate carcinoma | Homo sapiens | |||
| VCaP | CVCL_2235 | Prostate carcinoma | Homo sapiens | |||
| In-vivo Model | For a xenograft model, 2 * 106 VCaP cells per 0.1 ml suspended in a mixture of Matrigel and RPMI 1640 medium (1 : 1) were injected subcutaneously into the back of the mice. | |||||
| Experimental
Result(s) |
Phenethyl isothiocyanate in combination with dibenzoylmethane inhibits the androgenindependent growth of prostate cancer cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Phenethyl isothiocyanate in combination with dibenzoylmethane inhibits the androgen-independent growth of prostate cancer cells. Food Funct. 2018 Apr 25;9(4):2398-2408. | |||
