Drug Combination Details
| General Information of the Combination (ID: C22259) | |||||
|---|---|---|---|---|---|
| Name | Apalcillin NP Info | + | Gentamicin Drug Info | ||
| Structure |
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| Disease |
Pneumonia
[ICD-11: CA40]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | For a xenograft model, mice were made neutropenic by intraperitoneal (ip) injection of cyclophosphamide at a dose of 100 mg/kg on days 0, 2,4. | |||||
| Experimental
Result(s) |
Apalcillin when combined with gentamicin is effective in treating serious P. aeruginosa bacteraemia in neutropenic mice. | |||||
