Drug Combination Details
| General Information of the Combination (ID: C22380) | |||||
|---|---|---|---|---|---|
| Name | Gamma tocotrienol NP Info | + | Pravastatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Breast cancer
[ICD-11: 2C60]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ERK2 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | JNK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | p38 beta | Molecule Info |
Pathway MAP
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| In-vitro Model | Neoplastic mouse +SA mammary epithelial cells | Healthy | Rattus norvegicus | |||
| Experimental
Result(s) |
Treatment with subeffective doses of pravastatin or gamma-tocotrienol alone had no effect, whereas combined treatment of these compounds resulted in a relatively large decrease in intracellular levels of phosphorylated (activated) MAPK, JNK, p38, and Akt. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells. Lipids. 2007 Dec;42(12):1113-23. | |||
