Drug Combination Details
| General Information of the Combination (ID: C24748) | |||||
|---|---|---|---|---|---|
| Name | Arsenic trioxide NP Info | + | PX-478 Drug Info | ||
| Structure |
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+ |
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| Disease |
Pancreatic cancer
[ICD-11: 2C10]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | FOXO1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | HIF-1A | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| In-vitro Model | PANC-1 | CVCL_0480 | Pancreatic ductal adenocarcinoma | Homo sapiens | ||
| BxPC-3 | CVCL_0186 | Pancreatic ductal adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Arsenic trioxide plus PX-478 achieves effective treatment in pancreatic ductal adenocarcinoma. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Arsenic trioxide plus PX-478 achieves effective treatment in pancreatic ductal adenocarcinoma. Cancer Lett. 2016 Aug 10;378(2):87-96. | |||
