Drug Combination Details
| General Information of the Combination (ID: C26102) | |||||
|---|---|---|---|---|---|
| Name | Fosfomycin NP Info | + | Ciprofloxacin Drug Info | ||
| Structure |
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+ |
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| Disease |
Urinary tract infection
[ICD-11: GC08]
|
Phase 4 | [1] | ||
|
Shigella intestinal infection
[ICD-11: 1A02]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| In-vitro Model | Shigella flexneri isolates | Microorganism model | Shigella flexneri | |||
| Experimental
Result(s) |
Against CIPR S. flexneri isolates, the CIP/FOS combination induced synergy, and increased bacterial killing in vitro and in a simple invertebrate model of infection. | |||||
