Drug Combination Details
| General Information of the Combination (ID: C27097) | |||||
|---|---|---|---|---|---|
| Name | Elemene NP Info | + | Temozolomide Drug Info | ||
| Structure |
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+ |
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| Disease |
Brain cancer
[ICD-11: 2A00]
|
Phase 2 | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ATM | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | ERK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | H2AFX | Molecule Info |
Pathway MAP
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| In-vitro Model | U-87MG ATCC | CVCL_0022 | Glioblastoma | Homo sapiens | ||
| T98G | CVCL_0556 | Glioblastoma | Homo sapiens | |||
| U-251MG | CVCL_0021 | Astrocytoma | Homo sapiens | |||
| LN-229 | CVCL_0393 | Glioblastoma | Homo sapiens | |||
| C6 | CVCL_0194 | Rat malignant glioma | Rattus norvegicus | |||
| Experimental
Result(s) |
Beta-elemene enhances both radiosensitivity and chemosensitivity of glioblastoma cells through the inhibition of the ATM signaling pathway. | |||||
