Drug Combination Details

General Information of the Combination (ID: C27119)
Name Lactobacillus plantarum   NP Info  + 5-fluorouracil   Drug Info 
Structure +
Disease
Colorectal cancer [ICD-11: 2B91]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Reversing Drug Resistance by This Combination
                 Reversing Drug Resistance     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Biological
                    Regulation		 Down-regulation cAMP content
                    In-vitro Model HT-29 CVCL_0320 Colon adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 GABA-producing L. plantarum is promising as an adjuvant treatment for 5-FU-resistant CRC, and its intervention in neurobiological signaling imply new possibilities for chemoprevention and the treatment of colon cancer-related diseases.
References
Reference 1 GABA-producing Lactobacillus plantarum inhibits metastatic properties and induces apoptosis of 5-FU-resistant colorectal cancer cells via GABA B receptor signaling. J Microbiol. 2021 Feb;59(2):202-216.
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