Natural Product (NP) Details
| General Information of the NP (ID: NP8525) | |||||
|---|---|---|---|---|---|
| Name |
Lactobacillus plantarum
|
||||
| Species Origin | Lactiplantibacillus plantarum ... | Click to Show/Hide | |||
| Lactiplantibacillus plantarum | |||||
| Disease | Functional constipation [ICD-11: DD91] | Phase 3 | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Resistance can be Reversed by This NP | ||||||
| 5-fluorouracil | Solid tumour/cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
|||||
| Biological
Regulation |
Down-regulation | cAMP content | ||||
| In-vitro Model | HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
GABA-producing L. plantarum is promising as an adjuvant treatment for 5-FU-resistant CRC, and its intervention in neurobiological signaling imply new possibilities for chemoprevention and the treatment of colon cancer-related diseases. | |||||
