Drug Combination Details
| General Information of the Combination (ID: C27192) | |||||
|---|---|---|---|---|---|
| Name | Rofecoxib NP Info | + | Ionizing radiation Drug Info | ||
| Structure |
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+ |
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| Disease |
Solid tumour/cancer
[ICD-11: 2A00-2F9Z]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Cells isolated from T-75 Nunclon tissue | Healthy | Homo sapiens | |||
| Experimental
Result(s) |
Rofecoxib inhibited endothelial cell proliferation, migration, and tube formation (differentiation) at clinically relevant doses. In combination with radiation, inhibition of endothelial cell function further increased twofold. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Targeting angiogenic processes by combination rofecoxib and ionizing radiation. Am J Clin Oncol. 2001 Oct;24(5):438-42. | |||
