Drug Details
| General Information of the Drug (ID: DR6157) | ||||
|---|---|---|---|---|
| Name |
Ionizing radiation
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| Molecular Type |
Radiotherapy
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| Disease | Renal Insufficiency [ICD-11: GB6Z] | Phase 3 | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| 12-O-tetradecanoyl phorbol-13-acetate | Homo sapiens | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Biological
Regulation |
Induction | ROS accumulation | ||||
| In-vitro Model | K-562 | CVCL_0004 | Chronic myelogenous leukemia | Homo sapiens | ||
| Experimental
Result(s) |
Ionizing radiation enhances PMA-induced megakaryocytic differentiation at a relatively late phase, and that the late-phase accelerated differentiation depends on the persistence of the intracellular ROS level. | |||||
| Beta lapachone | Tabebuia avellanedae | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| In-vitro Model | DU145 | CVCL_0105 | Prostate carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
The synergistic interaction between beta-lap and radiation in killing cells is the result of two distinct mechanisms: First, radiation sensitizes cells to beta-lap by up-regulating NQO1, and second, beta-lap sensitizes cells to radiation by inhibiting SLD repair. | |||||
| Costunolide | Magnolia sieboldii | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [4] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
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| Molecule(s)
Regulation |
Up-regulation | Expression | CCNB1 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | CDK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | MPIP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | RAD53 | Molecule Info |
Pathway MAP
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| In-vitro Model | HA22T/VGH | CVCL_7046 | Adult hepatocellular carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells. | |||||
| Cucurbitacin I | Citrullus lanatus | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [5] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
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| In-vitro Model | Cells derived from NSCLC patients | Non-small cell lung cancer | Homo sapiens | |||
| Experimental
Result(s) |
Targeting STAT3 signaling in CD133-positive NSCLC cells with cucurbitacin I suppressed CSC-like properties and enhanced chemoradiotherapy response. | |||||
| Dihydroisotanshinone 1 | Salvia trijuga | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [6] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
|||||
| Molecule(s)
Regulation |
Down-regulation | Expression | MSH3 | Molecule Info |
Pathway MAP
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| In-vitro Model | DU145 | CVCL_0105 | Prostate carcinoma | Homo sapiens | ||
| PC-3 | CVCL_0035 | Prostate carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Dihydroisotanshinone I combined with radiation inhibits the migration ability of prostate cancer cells through DNA damage and CCL2 pathway. | |||||
| Rofecoxib | Homo sapiens | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [7] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
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| In-vitro Model | Cells isolated from T-75 Nunclon tissue | Healthy | Homo sapiens | |||
| Experimental
Result(s) |
Rofecoxib inhibited endothelial cell proliferation, migration, and tube formation (differentiation) at clinically relevant doses. In combination with radiation, inhibition of endothelial cell function further increased twofold. | |||||
| Selenium | Soil | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [8] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
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| In-vitro Model | NCI-H460 | CVCL_0459 | Lung large cell carcinoma | Homo sapiens | ||
| NCI-H1299 | CVCL_0060 | Lung large cell carcinoma | Homo sapiens | |||
| WI-38 | CVCL_0579 | Healthy | Homo sapiens | |||
| Experimental
Result(s) |
Selenium selectively enhanced the radiosensitivity of the tumor cells whereas that of the normal cells was unaffected. | |||||
| β. A List of Natural Product(s) Able to Decrease the Adverse Effect of This Drug | ||||||
| Asiaticoside | Centella asiatica | Click to Show/Hide the Molecular Data of This NP | ||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [9] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
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| In-vivo Model | C57BL/6J mice (8-10 weeks old, male), which have been shown to be radiation sensitive, were housed five animals per cage under controlled conditions and received standard laboratory diet through the course of the experiment. | |||||
| Experimental
Result(s) |
AC is able to prevent radiation-initiated genotoxicity by mitigating DNA damage. | |||||
