Drug Combination Details
| General Information of the Combination (ID: C77126) | |||||
|---|---|---|---|---|---|
| Name | Selenium NP Info | + | Ionizing radiation Drug Info | ||
| Structure |
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| Disease |
Lung cancer
[ICD-11: 2C25]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | NCI-H460 | CVCL_0459 | Lung large cell carcinoma | Homo sapiens | ||
| NCI-H1299 | CVCL_0060 | Lung large cell carcinoma | Homo sapiens | |||
| WI-38 | CVCL_0579 | Healthy | Homo sapiens | |||
| Experimental
Result(s) |
Selenium selectively enhanced the radiosensitivity of the tumor cells whereas that of the normal cells was unaffected. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Enhanced lung cancer cell killing by the combination of selenium and ionizing radiation. Oncol Rep. 2007 Jan;17(1):209-16. | |||
