Drug Combination Details

General Information of the Combination (ID: C28255)
Name 12-O-tetradecanoyl phorbol-13-acetate   NP Info  + Ionizing radiation   Drug Info 
Structure +
Disease
Acute lymphoblastic leukemia [ICD-11: 2B33]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Biological
                    Regulation		 Induction ROS accumulation
                    In-vitro Model K-562 CVCL_0004 Chronic myelogenous leukemia Homo sapiens
                    Experimental
                    Result(s)		 Ionizing radiation enhances PMA-induced megakaryocytic differentiation at a relatively late phase, and that the late-phase accelerated differentiation depends on the persistence of the intracellular ROS level.
References
Reference 1 Megakaryocytic differentiation in human chronic myelogenous leukemia K562 cells induced by ionizing radiation in combination with phorbol 12-myristate 13-acetate. J Radiat Res. 2013 May;54(3):438-46.
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