Natural Product (NP) Details
| General Information of the NP (ID: NP1197) | |||||
|---|---|---|---|---|---|
| Name |
12-O-tetradecanoyl phorbol-13-acetate
|
||||
| Synonyms |
TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate
Click to Show/Hide
|
||||
| Species Origin | Homo sapiens ... | Click to Show/Hide | |||
| Homo sapiens | |||||
| Disease | Acute myeloid leukemia [ICD-11: 2A60] | Phase 2 | [1] | ||
| Structure |
|
Click to Download Mol2D MOL |
|||
| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | |||||
| Formula |
C36H56O8
|
||||
| PubChem CID | |||||
| Canonical SMILES |
CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
|
||||
| InChI |
1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
|
||||
| InChIKey |
PHEDXBVPIONUQT-RGYGYFBISA-N
|
||||
| CAS Number |
CAS 16561-29-8
|
||||
| TTD Drug ID | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Ionizing radiation | Renal Insufficiency | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
|||||
| Biological
Regulation |
Induction | ROS accumulation | ||||
| In-vitro Model | K-562 | CVCL_0004 | Chronic myelogenous leukemia | Homo sapiens | ||
| Experimental
Result(s) |
Ionizing radiation enhances PMA-induced megakaryocytic differentiation at a relatively late phase, and that the late-phase accelerated differentiation depends on the persistence of the intracellular ROS level. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Potassium channel J5 Kir3.4 (KCNJ5) | Molecule Info | [3] | |
| Potassium channel T1 KCa4.1 (KCNT1) | Molecule Info | [4] | ||
| Potassium channel T2 KCa4.2 (KCNT2) | Molecule Info | [4] | ||
| Transient receptor cation channel V4 (TRPV4) | Molecule Info | [5] | ||
| KEGG Pathway | Circadian entrainment | Click to Show/Hide | ||
| 2 | Retrograde endocannabinoid signaling | |||
| 3 | Serotonergic synapse | |||
| 4 | Dopaminergic synapse | |||
| 5 | Estrogen signaling pathway | |||
| 6 | Oxytocin signaling pathway | |||
| 7 | Morphine addiction | |||
| 8 | Inflammatory mediator regulation of TRP channels | |||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | Click to Show/Hide | ||
| 2 | Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||
| Pathwhiz Pathway | Muscle/Heart Contraction | Click to Show/Hide | ||
| Reactome | Activation of G protein gated Potassium channels | Click to Show/Hide | ||
| 2 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | |||
| 3 | TRP channels | |||
| WikiPathways | Calcium Regulation in the Cardiac Cell | Click to Show/Hide | ||
| 2 | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| 3 | Notch Signaling Pathway | |||
| 4 | Potassium Channels | |||
