Drug Combination Details
| General Information of the Combination (ID: C53795) | |||||
|---|---|---|---|---|---|
| Name | Beta lapachone NP Info | + | Ionizing radiation Drug Info | ||
| Structure |
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+ |
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| Disease |
Prostate cancer
[ICD-11: 2C82]
|
Investigative | [1] | ||
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Colon cancer
[ICD-11: 2B90]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | DU145 | CVCL_0105 | Prostate carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
The synergistic interaction between beta-lap and radiation in killing cells is the result of two distinct mechanisms: First, radiation sensitizes cells to beta-lap by up-regulating NQO1, and second, beta-lap sensitizes cells to radiation by inhibiting SLD repair. | |||||
