Drug Combination Details
| General Information of the Combination (ID: C27680) | |||||
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| Name | Gentiopicroside | + | Leflunomide + Methotrexate | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Gentiopicroside NP Info | Drug Info | |||
| Structure |
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| Name | Drug Info | ||||
| Structure |
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| Disease |
Rheumatoid arthritis
[ICD-11: FA20]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | IL1B | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | IL6 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TNF | Molecule Info |
Pathway MAP
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| In-vivo Model | SD rats (200 g +/- 20 g) were used in this study. | |||||
| Experimental
Result(s) |
Gentiopicroside (GPS) could exert hepatoprotective effects on leflunomide (LEF)- and/or methotrexate (MTX)-treated arthritic rats. | |||||
| References | ||||
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| Reference 1 | Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats. Life Sci. 2021 Jan 15;265:118689. | |||
