Drug Combination Details
| General Information of the Combination (ID: C28119) | |||||
|---|---|---|---|---|---|
| Name | Caspofungin acetate NP Info | + | Amphotericin B Drug Info | ||
| Structure |
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| Disease |
Aspergillosis
[ICD-11: 1F20]
|
Phase 4 | [1] | ||
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Mucormycosis
[ICD-11: 1F2C]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| In-vivo Model | For a xenograft model, mice were rendered diabetic with a single intraperitoneal injection of 210 mg of streptozocin per kg of body weight. | |||||
| Experimental
Result(s) |
Combination therapy improved survival compared to that of mice given monotherapy and that of untreated controls (P < 0.05) but did not improve organ clearance. | |||||
