Drug Combination Details

General Information of the Combination (ID: C28144)
Name Flavopiridol   NP Info  + Pyrrolo-1,5-benzoxazepine   Drug Info 
Structure +
Disease
Chronic myelogenous leukaemia [ICD-11: 2A20]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Down-regulation Expression BIRC5  Molecule Info 
Pathway MAP
Down-regulation Expression CCNB1  Molecule Info 
Pathway MAP
Down-regulation Expression CDK1  Molecule Info 
Pathway MAP
                    Biological
                    Regulation		 Acceleration Exit from G2/M transition
                    In-vitro Model K-562 CVCL_0004 Chronic myelogenous leukemia Homo sapiens
LAMA-84 CVCL_0388 Chronic myelogenous leukemia Homo sapiens
Ba/F3 CVCL_0161 Healthy Mus musculus
                    Experimental
                    Result(s)		 Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells.
References
Reference 1 Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment. Biochem Pharmacol. 2010 Jul 1;80(1):31-8.
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