Drug Details
| General Information of the Drug (ID: DR9185) | ||||
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| Name |
Pyrrolo-1,5-benzoxazepine
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| Synonyms |
SCHEMBL5185374; 2H-pyrrolo[2,3-i][1,5]benzoxazepine
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| Molecular Type |
Small molecule
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| Disease | Colorectal cancer [ICD-11: 2B91] | Investigative | [1] | |
| Structure |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | ||||
| Formula |
C11H8N2O
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| PubChem CID | ||||
| Canonical SMILES |
C1C=CN=C2C=CC3=NC=CC3=C2O1
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| InChI |
1S/C11H8N2O/c1-5-12-10-3-2-9-8(4-6-13-9)11(10)14-7-1/h1-6H,7H2
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| InChIKey |
UNHWZPWLXOALOM-UHFFFAOYSA-N
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Flavopiridol | Dysoxylum binectariferum | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Molecule(s)
Regulation |
Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCNB1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK1 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Acceleration | Exit from G2/M transition | ||||
| In-vitro Model | K-562 | CVCL_0004 | Chronic myelogenous leukemia | Homo sapiens | ||
| LAMA-84 | CVCL_0388 | Chronic myelogenous leukemia | Homo sapiens | |||
| Ba/F3 | CVCL_0161 | Healthy | Mus musculus | |||
| Experimental
Result(s) |
Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells. | |||||
