Drug Combination Details
| General Information of the Combination (ID: C28146) | |||||
|---|---|---|---|---|---|
| Name | Human plasma cholinesterase NP Info | + | Edrophonium Drug Info | ||
| Structure |
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+ |
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| Disease |
Neuromuscular blockage
[ICD-11: NE60]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Reversing Drug Resistance by This Combination | ||||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Clinical Trial | |||||
| Experimental
Result(s) |
The edrophonium-PCHE combination significantly accelerated recovery of mivacurium-induced block compared with that observed with the use of individual antagonists. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Edrophonium and human plasma cholinesterase combination for antagonism of mivacurium-induced neuromuscular block. Br J Anaesth. 1996 Sep;77(3):424-6. | |||
