Natural Product (NP) Details
| General Information of the NP (ID: NP6573) | |||||
|---|---|---|---|---|---|
| Name |
Human plasma cholinesterase
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| Species Origin | Homo sapiens ... | Click to Show/Hide | |||
| Homo sapiens | |||||
| Disease | Neuromuscular blockage [ICD-11: NE60] | Phase 1 | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Resistance can be Reversed by This NP | ||||||
| Edrophonium | Myasthenia gravis | Click to Show/Hide the Molecular Data of This Drug | ||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| In-vivo Model | Clinical Trial | |||||
| Experimental
Result(s) |
The edrophonium-PCHE combination significantly accelerated recovery of mivacurium-induced block compared with that observed with the use of individual antagonists. | |||||
