Drug Combination Details

General Information of the Combination (ID: C28779)
Name Flavopiridol   NP Info  + Doxorubicin   Drug Info 
Structure +
Disease
Sarcoma [ICD-11: 2A60-2C35]
Phase 1 [1]
Hepatocellular carcinoma [ICD-11: 2C12]
Investigative [2]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    Molecule(s)
                    Regulation		 Down-regulation Expression NDRG1  Molecule Info 
Pathway MAP
                    In-vivo Model Subcutaneous injections of 2.5*105 viable MH134 cells suspended in 0.1 mL of media were performed in the right flanks of five-week-old male C3H/He mice, creating a bleb.
                    Experimental
                    Result(s)		 Combination of doxorubicin and flavopiridol has a synergistic anti-tumor effect in an in vivo HCC model.
References
Reference 1 ClinicalTrials.gov (NCT00098579) Doxorubicin Hydrochloride and Alvocidib in Treating Patients With Metastatic or Recurrent Sarcoma That Cannot Be Removed By Surgery U.S. National Institutes of Health.
Reference 2 Synergistic anti-tumor efficacy of doxorubicin and flavopiridol in an in vivo hepatocellular carcinoma model. J Cancer Res Clin Oncol. 2015 Nov;141(11):2037-45.
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