Drug Combination Details
| General Information of the Combination (ID: C28982) | |||||
|---|---|---|---|---|---|
| Name | Tretinoin NP Info | + | Primaquin Drug Info | ||
| Structure |
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+ |
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| Disease |
Pneumocystosis
[ICD-11: 1F2G]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
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| In-vivo Model | C57BL/6 micemice were transtracheally instilled with 2*106 of Pc organisms in 50 uL sterile PBS. | |||||
| Experimental
Result(s) |
All-trans retinoic acid in combination with primaquine clears pneumocystis infection. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | All-trans retinoic acid in combination with primaquine clears pneumocystis infection. PLoS One. 2013;8(1):e53479. | |||
