Drug Combination Details
| General Information of the Combination (ID: C29576) | |||||
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| Name | Tretinoin | + | Hydroquinone + Fluocinolone acetonide | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Tretinoin NP Info | Drug Info | |||
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| Disease |
Acquired hypermelanosis
[ICD-11: ED60]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Clinical trial | |||||
| Experimental
Result(s) |
Combination therapy with hydroquinone, tretinoin, and fluocinolone is the most cost-effective treatment when compared with any of its dyads or with hydroquinone alone. | |||||
| References | ||||
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| Reference 1 | Cost-effectiveness of a hydroquinone/tretinoin/fluocinolone acetonide cream combination in treating melasma in the United States. J Dermatolog Treat. 2010 Sep;21(5):276-81. | |||
